Ethan Hunt and his team are racing against time to track down a dangerous terrorist named Hendricks, who has gained access to Russian nuclear launch codes and is planning a strike on the United States. An attempt to stop him ends in an explosion causing severe destruction to the Kremlin and the IMF to be implicated in the bombing, forcing the President to disavow them. No longer being aided by the government, Ethan and his team chase Hendricks around the globe, although they might still be too late to stop a disaster.

Set against the backdrop of the greatest clandestine race against time in the history of science with the mission to build the world's first atomic bomb in Los Alamos, New Mexico. Flawed scientists and their families attempt to co-exist in a world where secrets and lies infiltrate every aspect of their lives.