100 years in the future, planetary colonization missions have begun as a necessity to help secure the survival of the human race. The first of these missions on a spacecraft known as Ark One encounters a catastrophic event causing massive destruction and loss of life. With more than a year left to go before reaching their target planet, a lack of life-sustaining supplies and loss of leadership, the remaining crew must become the best versions of themselves to stay on course and survive.

After escaping with Newt and Hicks from the alien planet, Ripley crash lands on Fiorina 161, a prison planet and host to a correctional facility. Unfortunately, although Newt and Hicks do not survive the crash, a more unwelcome visitor does. The prison does not allow weapons of any kind, and with aid being a long time away, the prisoners must simply survive in any way they can.