For years, Blade has fought against the vampires in the cover of the night. But now, after falling into the crosshairs of the FBI, he is forced out into the daylight, where he is driven to join forces with a clan of human vampire hunters he never knew existed—The Nightstalkers. Together with Abigail and Hannibal, two deftly trained Nightstalkers, Blade follows a trail of blood to the ancient creature that is also hunting him—the original vampire, Dracula.

In an isolated family mansion, a group of rich 20-somethings decides to play Bodies Bodies Bodies, a game where one of them is secretly a "killer" while the rest tries to "escape". Things take a turn for the worse when real bodies start turning up, setting off a paranoid and dangerous chain of events.