Year 198 of the Solar Era in Tokyo, special fire brigades are fighting against a phenomenon called spontaneous human combustion where humans beings are turned into living infernos called "Infernals". While the Infernals are first generation cases of spontaneous human combustion, later generations possess the ability to manipulate flames while retaining human form. Shinra Kusakabe, a youth who gained the nickname Devil's Footprints for his ability to ignite his feet at will, joins the Special Fire Force Company 8 which composes of other flames users as they work to extinguish any Infernals they encounter. As a faction that is creating Infernals appears, Shira begins to uncover the truth behind a mysterious fire that caused the death of his family twelve years ago.

An edge-of-your-seat view into the lives of everyday heroes committed to one of America's noblest professions. For the firefighters, rescue squad and paramedics of Chicago Firehouse 51, no occupation is more stressful or dangerous, yet so rewarding and exhilarating. These courageous men and women are among the elite who forge headfirst into danger when everyone else is running the other way and whose actions make the difference between life and death.

Seeking redemption and a shortened prison sentence, young convict Bode Donovan joins a firefighting program that returns him to his small Northern California hometown, where he and other inmates work alongside elite firefighters to extinguish massive blazes across the region.