Ethan Hunt and his IMF team embark on their most dangerous mission yet: To track down a terrifying new weapon that threatens all of humanity before it falls into the wrong hands. With control of the future and the world's fate at stake and dark forces from Ethan's past closing in, a deadly race around the globe begins. Confronted by a mysterious, all-powerful enemy, Ethan must consider that nothing can matter more than his mission—not even the lives of those he cares about most.

Despite pulling off one of the biggest heists in Las Vegas history and splitting the $160 million take, each of the infamous Ocean's crew have tried to go straight, lay low and live a legit life... but that's proven to be a challenge. Casino owner Terry Benedict demands that Danny Ocean return the money, plus millions more in interest. Unable to come up the cash, the crew is forced to come together to pull off another series of heists, this time in Rome, Paris, and Amsterdam – but a Europol agent is hot on their heels.