Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.

Driver is a skilled Hollywood stuntman who moonlights as a getaway driver for criminals. Though he projects an icy exterior, lately he's been warming up to a pretty neighbor named Irene and her young son, Benicio. When Irene's husband gets out of jail, he enlists Driver's help in a million-dollar heist. The job goes horribly wrong, and Driver must risk his life to protect Irene and Benicio from the vengeful masterminds behind the robbery.