The Vampire Lestat goes on tour while being haunted by "muses" from his past. As the band's popularity grows, so does Lestat's influence over vampires & humans alike, leaving others to contend with Lestat's power in the face of the Great Conversion.

A century-old vampire from New Orleans reunites with an ailing journalist to recount his life of bloodlust and his tumultuous relationship with the rakish Frenchman who turned him.