In an isolated family mansion, a group of rich 20-somethings decides to play Bodies Bodies Bodies, a game where one of them is secretly a "killer" while the rest tries to "escape". Things take a turn for the worse when real bodies start turning up, setting off a paranoid and dangerous chain of events.

When renowned crime novelist Harlan Thrombey is found dead at his estate just after his 85th birthday, the inquisitive and debonair Detective Benoit Blanc is mysteriously enlisted to investigate. From Harlan's dysfunctional family to his devoted staff, Blanc sifts through a web of red herrings and self-serving lies to uncover the truth behind Harlan's untimely death.