When an IMF mission ends badly, the world is faced with dire consequences. As Ethan Hunt takes it upon himself to fulfill his original briefing, the CIA begin to question his loyalty and his motives. The IMF team find themselves in a race against time, hunted by assassins while trying to prevent a global catastrophe.

Ethan Hunt and team continue their search for the terrifying AI known as the Entity — which has infiltrated intelligence networks all over the globe — with the world's governments and a mysterious ghost from Hunt's past on their trail. Joined by new allies and armed with the means to shut the Entity down for good, Hunt is in a race against time to prevent the world as we know it from changing forever.