Their first week of high school. The biggest party of the year. Mistakes will be made as four teenage boys navigate a night of mayhem and debauchery.

When cops Schmidt and Jenko join the secret Jump Street unit, they use their youthful appearances to go undercover as high school students. They trade in their guns and badges for backpacks, and set out to shut down a dangerous drug ring. But, as time goes on, Schmidt and Jenko discover that high school is nothing like it was just a few years earlier -- and, what's more, they must again confront the teenage terror and anxiety they thought they had left behind.

In the wake of a school tragedy, Vada, Mia and Quinton form a unique and dynamic bond as they navigate the never linear, often confusing journey to heal in a world that feels forever changed.