In Tree Hill, North Carolina two half brothers share a last name and nothing else. Brooding, blue-collar Lucas is a talented street-side basketball player, but his skills are appreciated only by his friends at the river court. Popular, affluent Nathan basks in the hero-worship of the town, as the star of his high school team. And both boys are the son of former college ball player Dan Scott whose long ago choice to abandon Lucas and his mother Karen, will haunt him long into his life with wife Deb and their son Nathan.

Physicists Leonard and Sheldon find their nerd-centric social circle with pals Howard and Raj expanding when aspiring actress Penny moves in next door.

A hedonistic jingle writer's free-wheeling life comes to an abrupt halt when his brother and 10-year-old nephew move into his beach-front house.

FBI Special Agent Olivia Dunham, brilliant but formerly institutionalized scientist Walter Bishop and his scheming, reluctant son Peter uncover a deadly mystery involving a series of unbelievable events and realize they may be a part of a larger, more disturbing pattern that blurs the line between science fiction and technology.

Atlantic City at the dawn of Prohibition is a place where the rules don't apply. And the man who runs things -- legally and otherwise -- is the town's treasurer, Enoch "Nucky" Thompson, who is equal parts politician and gangster.

Film star Vince Chase navigates the vapid terrain of Los Angeles with a close circle of friends and his trusty agent.

An exclusive group of privileged teens from a posh prep school on Manhattan's Upper East Side whose lives revolve around the blog of the all-knowing albeit ultra-secretive Gossip Girl.

Based on the Pretty Little Liars series of young adult novels by Sara Shepard, the series follows the lives of four girls — Spencer, Hanna, Aria, and Emily — whose clique falls apart after the disappearance of their queen bee, Alison. One year later, they begin receiving messages from someone using the name "A" who threatens to expose their secrets — including long-hidden ones they thought only Alison knew.

The off-kilter, unscripted comic vision of Larry David, who plays himself in a parallel universe in which he can't seem to do anything right, and, by his standards, neither can anyone else.

Ryan Atwood, a teen from the wrong side of the tracks, moves in with a wealthy family willing to give him a chance. But Ryan's arrival disturbs the status quo of the affluent, privileged community of Newport Beach, California.

Years after he turned his back on his hometown, a burned-out major league ballplayer returns to teach phys ed at his old middle school.

The story of two vampire brothers obsessed with the same girl, who bears a striking resemblance to the beautiful but ruthless vampire they knew and loved in 1864.

A group of high school students navigate love and friendships in a world of drugs, sex, trauma, and social media.

The staff of Pittsburgh's Trauma Medical Center work around the clock to save lives in an overcrowded and underfunded emergency department.

On a college campus, an author navigates a complicated relationship with his daughter.